Browsing by Author "Djikic, Teodora"
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Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors
Coskun, Goeknil Pelin; Djikic, Teodora; Hayal, Taha Bartu; Turkel, Nezaket; Yelekci, Kemal; Sahin, Fikrettin; Kucukguzel, S. Guniz (MDPI, 2018)Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with cancer activity was recently discovered. In ... -
Synthesis, Molecular Modelling and Antibacterial Activity Against Helicobacter pylori of Novel Diflunisal Derivatives as Urease Enzyme Inhibitors
Coskun, Goknil Pelin; Djikic, Teodora; Kalayci, Sadik; Yelekci, Kemal; Sahin, Fikrettin; Kucukguzel, S. Guniz (BENTHAM SCIENCE PUBL LTD, 2019)Background: The main factor for the prolongation of the ulcer treatment in the gastrointestinal system would be Helicobacter pylori infection, which can possibly lead to gastrointestinal cancer. Triple therapy is the ...